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I've tried to download v2.5 OS as that's the one that appears in the Proteus session editor software, but nothing happens on the PC or the proteus- i've checked the com port selection, cable and am in DL mode. i've got a fairly new PC that just has 5v/9v/12v next the the com ports, so am not sure whether they are the correct type, but the connector fits.
What kind of PC do you have. It's possible that the com port may not be enabled. I'll try and help if you give me a little more info on the make/model of your computer.